MHRA approves world’s first low-carbon version of COPD inhaler Trixeo Aerosphere

On May 12, 2025, the Medicines and Healthcare products Regulatory Agency (MHRA) issued an update regarding MHRA approves world’s first low-carbon version of COPD inhaler Trixeo Aerosphere. The new version uses HFO-1234ze(E), a propellant with near-zero global warming potential, replacing HFA-134a in the current version, which is equally safe and effective. This approval supports continued access to a widely used COPD treatment while enabling a transition to lower-carbon inhalers without compromising safety or quality.